Article
Epidemiologically closely related viruses from hemophilia B patients display high homology in two hypervariable regions of the HIV-1 env gene.
AIDS research and human retroviruses - 1 Apr 1991
Kleim J P, Ackermann A, Brackmann H H, Gahr M, Schneweis K E
Abstract excerpt
The diversity of human immunodeficiency virus type 1 (HIV-1) is mainly caused by mutations that affect the gene encoding the gp120 envelope protein. Isolates differ to a large extent in the hypervariable regions of gp120. This study was undertaken to determine the degree of variation of HIV-1 env...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Viral
- Electrophoresis, Polyacrylamide Gel
- Genes, env
- Genetic Variation
- HIV-1
- Hemophilia B
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Proviruses
- Sequence Homology, Nucleic Acid