Article
Hepatitis C virus-specific CD4+ T cell response after liver transplantation occurs early, is multispecific, compartmentalizes to the liver, and does not correlate with recurrent disease.
The Journal of infectious diseases - 15 Apr 2001
Schirren C A, Jung M C, Worzfeld T, Mamin M, Baretton G, Gerlach J T, Gruener N H, Zachoval R, Houghton M, Rau H G, Pape G R
Abstract excerpt
The role of hepatitis C virus (HCV)-specific CD4+ T cells in recurrent HCV infection after orthotopic liver transplantation (OLTx) is unclear. In parallel, 73 intrahepatic and 73 blood-derived T cell lines were established from 34 patients. At a single cell level, virus-specific interferon (IFN)-gamma production to various HCV proteins was determined by ELISPOT assay: 45 (62%) of 73 liver- or blood-derived T cell...
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