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Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

9 Oct 2015

Abstract excerpt

BACKGROUND: The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunoglobulin gene-MYC fusion are the crucial initiating oncogenic events. However, Burkitt lymphoma cases with no detectable MYC rearrangement but maintaining MYC expression have been identified and...

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PMID: 26453442
DOI: 10.1186/s12885-015-1661-7

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