Article
Temporal variation in bacterial disease frequency: molecular population genetic analysis of scarlet fever epidemics in Ottawa and in eastern Germany.
The Journal of infectious diseases - 1 Mar 1993
Musser J M, Nelson K, Selander R K, Gerlach D, Huang J C, Kapur V, Kanjilal S
Abstract excerpt
In an effort to understand the molecular genetic basis of temporal variation in frequency and severity of bacterial disease, genetic relationships among strains of Streptococcus pyogenes that caused scarlet fever epidemics in Canada in the early 1940s and in eastern Germany in the 1960s to 1980s were studied. Application of multilocus enzyme electrophoresis and comparative sequencing of the gene (speA) encoding...
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