Article
Geographic and temporal distribution and molecular characterization of two highly pathogenic clones of Streptococcus pyogenes expressing allelic variants of pyrogenic exotoxin A (Scarlet fever toxin).
The Journal of infectious diseases - 1 Feb 1993
Musser J M, Kapur V, Kanjilal S, Shah U, Musher D M, Barg N L, Johnston K H, Schlievert P M, Henrichsen J, Gerlach D
Abstract excerpt
The molecular population genetics and pathogenic potential of North American and European invasive strains of Streptococcus pyogenes were assessed. Isolates from recent invasive infections and from infections in the 1920s and 1930s were characterized for multilocus enzyme genotype and allelic variation in the gene (speA) that encodes streptococcal pyrogenic exotoxin (SPE) A (scarlet fever toxin). A subset of...
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