Article
Characterization and clonal distribution of four alleles of the speA gene encoding pyrogenic exotoxin A (scarlet fever toxin) in Streptococcus pyogenes.
The Journal of experimental medicine - 1 Nov 1991
Nelson K, Schlievert P M, Selander R K, Musser J M
Abstract excerpt
Streptococcus pyogenes strains producing pyrogenic exotoxin A (scarlet fever toxin) have recently caused episodes of streptococcal toxic-shock-like syndrome (TSLS). We exploited knowledge of genetic diversity and relationships among exotoxin A-producing patient strains provided by multilocus enzyme electrophoresis to select strains for comparative sequencing of toxin genes. Our analysis identified four alleles of...
Topics
- Alleles
- Bacterial Proteins
- Base Sequence
- Exotoxins
- Genes, Bacterial
- Genotype
- Membrane Proteins
- Streptococcus pyogenes
- Structure-Activity Relationship