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Article

The hPMS2 exon 5 mutation and malignant glioma. Case report.

Journal of neurosurgery - 1 May 1999

Taylor M D, Perry J, Zlatescu M C, Stemmer-Rachamimov A O, Ang L C, Ino Y, Schwartz M, Becker L E, Louis D N, Cairncross J G

Abstract excerpt

Patients with Turcot syndrome (TS) are predisposed to colon tumors and primary brain tumors, typically glioblastomas or medulloblastomas. The authors describe a patient with TS featuring a known germline mutation of exon 5 of the hPMS2 mismatch repair gene who developed two metachronous glioblastomas, both with distinct oligodendroglial features. Molecular genetic analysis revealed allelic loss of chromosome 19q...

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Source

Identifiers

PMID: 10223463
DOI: 10.3171/jns.1999.90.5.0946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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