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Article

Mitochondrial DNA alterations as a source of human disorders.

Neurology - 1 Feb 1993

Tritschler H J, Medori R

Abstract excerpt

The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivity to mutagenic factors may account for the mitochondrial DNA polymorphism within ethnic groups...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8437690
DOI: 10.1212/wnl.43.2.280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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