Article
A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer.
American journal of human genetics - 1 Jan 1993
Lyn D, Cherney B W, Lalande M, Berenson J R, Lichtenstein A, Lupold S, Bhatia K G, Smulson M
Abstract excerpt
The poly(ADP-ribose) polymerase (PADPRP) gene (13q33-qter) depicts a two-allele (A/B) polymorphism. In the noncancer population, the frequency of the B allele is higher among blacks than among whites. Since the incidence of multiple myeloma and prostate and lung cancer is higher in the U.S. black population, we have analyzed the B-allele frequency in germ-line DNA to determine whether the PADPRP gene correlates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.