Article
Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.
Pharmacogenetics - 1 Aug 1997
Hu J J, Roush G C, Dubin N, Berwick M, Roses D F, Harris M N
Abstract excerpt
The importance of a genetic polymorphism (A/B allele) of poly(ADP-ribose) polymerase (PARP) pseudogene on chromosome 13q34-qter, and PARP enzyme activities in the development of human breast cancer were evaluated in a cancer case-control study. A total of 309 Caucasian women (> or = 50 years old) were evaluated for the PARP genotype, 70 of whom had histologically confirmed breast cancer, 128 women with benign...
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