Article
Deletion of genetic material from a poly(ADP-ribose) polymerase-like gene on chromosome 13 occurs frequently in patients with monoclonal gammopathies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Cao J, Hong C H, Rosen L, Vescio R A, Smulson M, Lichtenstein A K, Berenson J R
Abstract excerpt
Recently, by using a probe for the nuclear DNA repair enzyme poly(ADP-ribose) polymerase gene, a pseudogene was found on the long arm of chromosome 13. RFLP analysis demonstrates the presence of a common "A" allele and a rare "B" allele, which has a deletion of approximately 200 bp. This deletion...
Topics
- Alleles
- Black People
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- DNA, Complementary
- Humans
- Paraproteinemias
- Poly Adenosine Diphosphate Ribose
- Polymorphism, Restriction Fragment Length
- Proteins
- White People