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Article

Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.

The EMBO journal - 1 Jan 1993

Kara C J, Glimcher L H

Abstract excerpt

Class II-deficient combined immunodeficiency (CID) is a hereditary disease resulting in abrogation of transcription of the class II genes of the major histocompatibility complex, due to a defect in a trans-acting regulatory factor. Cell lines from certain CID patients lack factor binding at multiple sites in class II promoters in vivo. A mutation in one of the promoter binding proteins could explain this 'bare'...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8428578
DOI: 10.1002/j.1460-2075.1993.tb05644.x
PMCID: PMC413190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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