The effect of the Z mutation on the ability of alpha 1-antitrypsin to prevent neutrophil mediated tissue damage.

doi:10.1016/0925-4439(94)90089-2

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Article

The effect of the Z mutation on the ability of alpha 1-antitrypsin to prevent neutrophil mediated tissue damage.

Biochimica et biophysica acta - 29 Nov 1994

Llewellyn-Jones C G, Lomas D A, Carrell R W, Stockley R A

Abstract excerpt

Recent studies have shown that alpha 1-antitrypsin (alpha 1-AT) from Z antitrypsin deficiency subjects has a slightly lower association rate constant with neutrophil elastase (NE) than alpha 1-AT from normal subjects, although it is unknown whether this is of clinical importance. We have purified...

Topics

Connective Tissue
Fibronectins
Homozygote
Humans
Leukocyte Elastase
Mutation
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Pancreatic Elastase
Phenotype
alpha 1-Antitrypsin

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