Article
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.
The Journal of biological chemistry - 14 Jul 1995
Lomas D A, Elliott P R, Sidhar S K, Foreman R C, Finch J T, Cox D W, Whisstock J C, Carrell R W
Abstract excerpt
The Z (Glu342-->Lys) and Siiyama (Ser53-->Phe) deficiency variants of alpha 1-antitrypsin result in the retention of protein in the endoplasmic reticulum of the hepatocyte by loop-sheet polymerization in which the reactive center loop of one molecule is inserted into a beta-pleated sheet of a sec...
Topics
- Amino Acid Sequence
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymers
- Protein Conformation
- alpha 1-Antitrypsin