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Article

A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells.

Journal of autoimmunity - 1 Feb 2013

Hillhouse Erin E, Lesage Sylvie

Abstract excerpt

Double negative T cells that lack the expression of both CD4 and CD8 T cell co-receptors exhibit a most unique antigen-specific immunoregulatory potential first described over a decade ago. Due to their immunoregulatory function, this rare T cell population has been studied in both mice and humans for their contribution to peripheral tolerance and disease prevention. Consequently, double negative cells are...

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PMID: 22910322
DOI: 10.1016/j.jaut.2012.07.010

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