Article
Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.
1 Oct 1993
Abstract excerpt
Transgenic mice which carry hybrid p53 promoter-chloramphenicol acetyltransferase (CAT) transgenes were found to express CAT enzymatic activity predominantly in the testes. Endogenous levels of p53 mRNA and protein were lower than in the nontransgenic control mice. The various p53 promoter-CAT transgenic mice exhibited in their testes multinucleated giant cells, a degenerative syndrome resulting presumably from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.