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Article

Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22.

American journal of human genetics - 1 Feb 1990

Rouleau G A, Seizinger B R, Wertelecki W, Haines J L, Superneau D W, Martuza R L, Gusella J F

Abstract excerpt

Neurofibromatosis 2 or bilateral acoustic neurofibromatosis (NF2) is a severe autosomal dominant disorder characterized by the development of multiple tumors of the nervous system, including meningiomas, gliomas, neurofibromas, ependymomas, and particularly acoustic neuromas. Polymorphic DNA markers have revealed frequent loss of one copy of chromosome 22 in the tumor types associated with NF2. Family studies...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 22
DNA Probes
DNA, Neoplasm
Genetic Linkage
Genetic Markers
Humans
Lod Score
Lymphocytes
Neurofibromatosis 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroma, Acoustic

Restriction Mapping

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Open in PubMed Open full text

Identifiers

PMID: 2105641
PMCID: PMC1684964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2105641-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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