Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas.

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Article

Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas.

Oncogene - 21 Sept 1995

Porcellini A, Ciullo I, Pannain S, Fenzi G, Avvedimento E

Abstract excerpt

We have discovered two somatic mutations in the VI transmembrane domain of the thyrotropin receptor gene in thyroid hyperfunctioning adenomas. The mutated amino acid residues are phenylalanine 631 (to cysteine) and threonine 632 (to isoleucine). Cloning and expression of the mutated versions of t...

Topics

Adenoma
Amino Acid Sequence
Base Sequence
Cyclic AMP
GTP-Binding Proteins
Humans
Molecular Sequence Data
Mutation
Receptors, Thyrotropin
Thyroid Neoplasms
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7566968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7566968-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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