Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.

doi:10.1128/jb.176.23.7267-7273.1994

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Article

Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.

Journal of bacteriology - 1 Dec 1994

Carbonetti N H, Fuchs T M, Patamawenu A A, Irish T J, Deppisch H, Gross R

Abstract excerpt

In Bordetella pertussis, expression of virulence factors is controlled by the Bvg proteins, which comprise a sensor-regulator two-component signal transduction system. Previously, we described a mutant strain of B. pertussis that had reduced transcription of pertussis toxin and adenylate cyclase...

Topics

Adenylate Cyclase Toxin
Amino Acid Sequence
Base Sequence
Bordetella pertussis
DNA Repair
DNA-Directed RNA Polymerases
Down-Regulation
Gene Expression Regulation, Bacterial
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Pertussis Toxin

Phenotype

Promoter Regions, Genetic

Restriction Mapping

Species Specificity

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7961498
DOI: 10.1128/jb.176.23.7267-7273.1994
PMCID: PMC197115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7961498-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.PMID 7961498Read ↗

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