Origins of spontaneous mutants: cellular strategies for controlling their formation in response to changing environments.

Abstract excerpt

Spontaneous and induced mutational events may not be as readily distinguishable as has been generally assumed. It is suggested that the later stages of the processes leading to the establishment of fixation of mutations may consist of a 'mutational pathway', with many features in common with the better-known metabolic pathways of organisms like Escherichia coli. If so, the mutational pathway may be controlled by...

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