Article
T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis.
American journal of respiratory cell and molecular biology - 1 Oct 1993
Ying S, Durham S R, Barkans J, Masuyama K, Jacobson M, Rak S, Löwhagen O, Moqbel R, Kay A B, Hamid Q A
Abstract excerpt
We have investigated the phenotype of interleukin-5 (IL-5) mRNA+ cells in the nasal mucosa of subjects with allergic rhinitis. Serial cryostat sections were cut from paraformaldehyde-fixed snap-frozen nasal biopsies from six patients, before and 24 h after local allergen provocation with grass pollen. Immunocytochemistry (APAAP) was followed by in situ hybridization on the same sections. For immunocytochemistry,...
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