Article
Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis.
Allergology international : official journal of the Japanese Society of Allergology - 1 Apr 2017
Suzuki Motohiko, Yokota Makoto, Nakamura Yoshihisa, Ozaki Shinya, Murakami Shingo
Abstract excerpt
BACKGROUND: IL-35 was recently identified as an anti-inflammatory cytokine. We previously reported that recombinant fusion protein of murine IL-35 and human IgG1 Fc fragment (rIL-35) reduced Th2 cytokines (IL-4 and IL-5) in vitro. However, it is unclear whether IL-35 can attenuate nasal allergic responses and symptoms of allergic rhinitis in vivo. METHODS: To investigate the in vivo effect of IL-35 on allergic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.