The novel use of the human nasal epithelial cell line RPMI 2650 as an <i>in vitro</i> model to study the influence of allergens and cytokines on transforming growth factor‐β gene expression and protein release

Abstract excerpt

BACKGROUND: The epithelial accumulation of mast cells is a feature of allergic rhinitis and this has been linked to the expression of the known mast cell chemoattractant transforming growth factor-beta (TGF-beta) at this site. Little is known concerning the regulation of TGF-beta gene expression or protein release by nasal epithelial cells. To address this we have utilized the RPMI 2650 human nasal epithelial...

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