Article
Selection of variants of the TEM-1 beta-lactamase, encoded by a plasmid of clinical origin, with increased resistance to beta-lactamase inhibitors.
The Journal of antimicrobial chemotherapy - 1 May 1993
Thomson C J, Amyes S G
Abstract excerpt
A TEM-1 derived variant beta-lactamase with increased resistance to beta-lactamase inhibitors was selected in vitro. The variant beta-lactamase was obtained from the parent strain Escherichia coli J62-2 containing resistance plasmid R1 which encodes the TEM-1 beta-lactamase. The variants were obt...
Topics
- Amoxicillin
- Clavulanic Acid
- Clavulanic Acids
- Conjugation, Genetic
- Drug Resistance, Microbial
- Escherichia coli
- Isoelectric Focusing
- Microbial Sensitivity Tests
- Mutation
- Penicillanic Acid
- Plasmids
- Restriction Mapping
- Sulbactam
- Tazobactam
- beta-Lactamase Inhibitors
- beta-Lactamases