Article
Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2006
Sternlicht Mark D, Dunning Alison M, Moore Dan H, Pharoah Paul D P, Ginzinger David G, Chin Koei, Gray Joe W, Waldman Frederic M, Ponder Bruce A J, Werb Zena
Abstract excerpt
Plasminogen activator inhibitor-1 (PAI1) can promote cancer progression, and its protein expression in tumors is an independent indicator of poor prognosis in many forms of cancer. Here, we show that high PAI1 mRNA levels also predict for shorter overall survival in two independent breast cancer data sets, highlighting the importance of its transcriptional regulation. The -675insG (4G/5G) single-nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.