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Article

Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

1 May 1993

Abstract excerpt

The transforming function of human papillomavirus type 16 (HPV16) E7 has been shown to depend on activities additional to the ability to bind RB. In this paper we describe two further properties of E7 which may also contribute to transformation, an association with a histone H1 kinase at the G2/M phase of the cell cycle and an ability to bind the RB-related protein p107. The region of E7 identified previously as...

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PMID: 8386265
DOI: 10.1128/jvi.67.5.2521-2528.1993

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Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformationPMID 8386265Read ↗

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genesSemantic proximity Read ↗

HPV-16 E7 functions at the G1 to S phase transition in the cell cycle.Semantic proximity Read ↗

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsSemantic proximity Read ↗

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.Semantic proximity Read ↗

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinSemantic proximity Read ↗

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Semantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequencesSemantic proximity Read ↗

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the carcinogenic activity of the human papillomavirus E7 oncoproteinSemantic proximity Read ↗

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.Semantic proximity Read ↗

Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein.Semantic proximity Read ↗

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