Article
HPV-16 E7 functions at the G1 to S phase transition in the cell cycle.
Oncogene - 1 Jun 1990
Banks L, Barnett S C, Crook T
Abstract excerpt
Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilised a system of inducible expression of the E7 gene. The studies reported here show that...
Topics
- Animals
- Cell Cycle
- Cell Line
- DNA
- Fibroblasts
- Flow Cytometry
- Gene Expression Regulation, Viral
- Growth Substances
- Interphase
- Kidney
- Mice
- Oncogene Proteins, Viral