Article
The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.
The EMBO journal - 1 Jan 1990
Barbosa M S, Edmonds C, Fisher C, Schiller J T, Lowy D R, Vousden K H
Abstract excerpt
Some genital human papillomavirus (HPV) types, such as 16 and 18, are highly associated with malignant cervical tumors while others, such as HPV 6, are only rarely found in these malignancies. The E7 oncoproteins of HPV 6, 16 and 18 each have a 17 amino acid region with striking homology to adenovirus E1a and SV40 LT. E1a, LT and the E7 oncoprotein of HPV16 all bind the cellular Rb protein in vitro, and for E1a...
Topics
- Adenovirus Early Proteins
- Amino Acid Sequence
- Antigens, Viral, Tumor
- Casein Kinases
- Cell Line
- Cloning, Molecular
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral