Article
Rotavirus RNA variation during chronic infection of immunocompromised children.
Pediatric infectious disease - 1 Jan 2000
Eiden J, Losonsky G A, Johnson J, Yolken R H
Abstract excerpt
Polyacrylamide gel electrophoresis was performed on RNA from rotaviruses isolated from two immunocompromised patients with prolonged rotavirus diarrhea. Extensive variations were observed in the genomes of rotaviruses isolated from each patient during a 16-week period of their illness. An animal model of rotavirus infection was used to help evaluate the results found in our patients. Individual mouse rotavirus...
Topics
- Animals
- Child, Preschool
- Chronic Disease
- Diarrhea
- Electrophoresis, Polyacrylamide Gel
- Enzyme-Linked Immunosorbent Assay
- Genetic Variation
- Humans
- Immunologic Deficiency Syndromes
- Infant
- Male