Article
The nature and spatial distribution of amino acid substitutions conferring resistance to neutralizing monoclonal antibodies in human rhinovirus type 2.
The Journal of general virology - 1 Feb 1993
Speller S A, Sangar D V, Clarke B E, Rowlands D J
Abstract excerpt
A total of 38 neutralization escape mutant viruses have been selected from a cloned stock of human rhinovirus serotype 2 (HRV-2), using either of two monoclonal antibodies (MAbs) which recognize overlapping epitopes as judged by competition binding. The mutant viruses were analysed for their sens...
Topics
- Amino Acids
- Antibodies, Monoclonal
- Antibodies, Viral
- Enzyme-Linked Immunosorbent Assay
- Humans
- Models, Molecular
- Mutation
- Neutralization Tests
- Rhinovirus