Article
Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes.
The American journal of physiology - 1 Jan 1997
Davidoff A J, Ren J
Abstract excerpt
One of the most prominent myocardial defects associated with diabetes is abnormal diastole. We have recently reported that this dysfunction involves prolonged relaxation (relengthening) in isolated ventricular myocytes that occurs within days after the induction of diabetes. The present study was...
Topics
- Animals
- Calcium
- Cells, Cultured
- Culture Media
- Diabetes Mellitus, Experimental
- Dose-Response Relationship, Drug
- Glucose
- Insulin
- Intracellular Membranes
- Male
- Myocardial Contraction
- Myocardium
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Time Factors
- Ventricular Function