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Article

Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes.

The American journal of physiology - 1 Jan 1997

Davidoff A J, Ren J

Abstract excerpt

One of the most prominent myocardial defects associated with diabetes is abnormal diastole. We have recently reported that this dysfunction involves prolonged relaxation (relengthening) in isolated ventricular myocytes that occurs within days after the induction of diabetes. The present study was designed to evaluate the role of insulin and glucose int he etiology of this dysfunction with a serum-free myocyte...

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PMID: 9038934
DOI: 10.1152/ajpheart.1997.272.1.H159

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