Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

Article

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

Cancer research - 15 Sept 1993

Slichenmyer W J, Nelson W G, Slebos R J, Kastan M B

Abstract excerpt

Cell cycle checkpoints regulate progression through the cell cycle. In yeast, loss of the G2 checkpoint by mutation of the rad9 gene results in increased genetic instability as well as increased sensitivity to ionizing radiation. In contrast, comparing clonogenic survival of cells which are isoge...

Topics

Camptothecin
Cell Survival
DNA Damage
G1 Phase
Genes, p53
Humans
Mutation
Radiation Tolerance
Tumor Cells, Cultured

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