Article
Anti-phagocytic mechanisms of Streptococcus pyogenes: binding of fibrinogen to M-related protein.
Molecular microbiology - 1 Feb 2006
Courtney Harry S, Hasty David L, Dale James B
Abstract excerpt
A key attribute of invasive Streptococcus pyogenes is their ability to resist phagocytosis and multiply in human blood. M-related protein (Mrp) is a major anti-phagocytic factor but the mechanism whereby it helps streptococci to evade phagocytosis has not been demonstrated. We investigated phagocytosis resistance in a strain of serotype M4 by inactivating the mrp gene and also the emm, enn, sof and sfbX genes and...
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