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Article

Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes.

Molecular microbiology - 1 Mar 1995

Perez-Casal J, Okada N, Caparon M G, Scott J R

Abstract excerpt

The surface-located M protein functions to protect Streptococcus pyogenes (the group A streptococcus) from phagocytosis by polymorphonuclear leukocytes. It has been suggested that this protection results from the ability of M protein to bind factor H, a serum protein that can inhibit the activation of complement. Among different serological variants of M protein, the C-repeat domain is highly conserved and is...

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PMID: 7596292
DOI: 10.1111/j.1365-2958.1995.tb02360.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes.PMID 7596292Read ↗

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Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute VirulenceSemantic proximity Read ↗

Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathwaySemantic proximity Read ↗

An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes.Semantic proximity Read ↗

Interactions between M proteins of <i>Streptococcus pyogenes</i> and glycosaminoglycans promote bacterial adhesion to host cellsSemantic proximity Read ↗

Evasion of Phagocytosis through Cooperation between Two Ligand-binding Regions in <i>Streptococcus pyogenes</i> M ProteinSemantic proximity Read ↗

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M ProteinSemantic proximity Read ↗

Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system.Semantic proximity Read ↗

A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine DevelopmentSemantic proximity Read ↗

Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes.Semantic proximity Read ↗

Binding of human plasma proteins to Streptococcus pyogenes M protein determines the location of opsonic and non‐opsonic epitopesSemantic proximity Read ↗

Human C4b-Binding Protein Has Overlapping, But Not Identical, Binding Sites for C4b and Streptococcal M ProteinsSemantic proximity Read ↗

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