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Evasion of Phagocytosis through Cooperation between Two Ligand-binding Regions in <i>Streptococcus pyogenes</i> M Protein

29 Sept 2003

Abstract excerpt

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhibits the...

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PMID: 14517274
DOI: 10.1084/jem.20030543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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