Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.

doi:10.1038/364349a0

Back to search

Article

Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.

Nature - 22 Jul 1993

Hughes D A, Ashworth A, Marshall C J

Abstract excerpt

Intracellular signalling from receptor tyrosine kinases in mammalian cells involves the activation of a signal cascade which includes p21ras and the protein kinases p74raf-1, MAP kinase kinase and MAP kinases. In the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae the response to ma...

Topics

Animals
Enzyme Activation
Genetic Complementation Test
Mitogen-Activated Protein Kinase Kinases
Mutation
Phosphorylation
Protein Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Rabbits
Recombinant Fusion Proteins
Schizosaccharomyces

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.