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Article

Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.

Nature - 22 Jul 1993

Hughes D A, Ashworth A, Marshall C J

Abstract excerpt

Intracellular signalling from receptor tyrosine kinases in mammalian cells involves the activation of a signal cascade which includes p21ras and the protein kinases p74raf-1, MAP kinase kinase and MAP kinases. In the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae the response to mating pheromones requires the Spk1 and KSS1/FUS3 kinases, which have sequence homology to vertebrate MAP kinases. The...

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PMID: 8332194
DOI: 10.1038/364349a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.PMID 8332194Read ↗

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.Semantic proximity Read ↗

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.Semantic proximity Read ↗

Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

Functional analysis of domains in the Byr2 kinase.Semantic proximity Read ↗

Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.Semantic proximity Read ↗

Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.Semantic proximity Read ↗

The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.Semantic proximity Read ↗

The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner.Semantic proximity Read ↗

Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast.Semantic proximity Read ↗

Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction.Semantic proximity Read ↗

Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.Semantic proximity Read ↗

Raf-1 interferes with Ras and Rap1A effector functions in yeast.Semantic proximity Read ↗

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