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Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules

13 Mar 2009

Abstract excerpt

Sertoli cells, lining the walls of the seminiferous tubules, are in close contact with and regulate all aspects of the development of the germ cells. Clusterin, is a glycoprotein produced abundantly by Sertoli cells, and associated with either apoptosis or cell survival. Zinc is present in high concentrations in the testis and required for sperm development by an as yet unknown mechanism. Permeation of zinc into...

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PMID: 19288494
DOI: 10.1002/jcp.21754

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