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Article

The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations.

Mutation research - 1 Jan 1993

Fenech M

Abstract excerpt

The development of the cytokinesis-block (CB) technique has transformed the human-lymphocyte micronucleus assay (MN) into a reliable and precise method for assessing chromosome damage. Recent studies in our laboratory have confirmed that this method is a sensitive indicator of in vivo radiation exposure in (a) patients undergoing fractionated partial-body radiotherapy and (b) rodents exposed to uniform whole-body...

Topics

Animals
Cell Division
Cytarabine
DNA
DNA Damage
Female
Humans
Lymphocytes
Male
Micronuclei, Chromosome-Defective
Micronucleus Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7678131
DOI: 10.1016/0027-5107(93)90049-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7678131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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