Article
Leber's hereditary optic neuropathy. Clinical manifestations of the 15257 mutation.
Ophthalmology - 1 Jul 1993
Johns D R, Smith K H, Savino P J, Miller N R
Abstract excerpt
BACKGROUND: Leber's hereditary optic neuropathy is associated with four known pathogenetic mutations of mitochondrial DNA (mtDNA) at nucleotide positions (np) 11778, 3460, 15257, and 14484. METHODS: The authors collected clinical data from 12 visually symptomatic patients from seven different pedigrees with the 15257 mutation and compared these data with previously published clinical features of the 11778 and...
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