Leber's hereditary optic neuropathy. Clinical manifestations of the 14484 mutation.

doi:10.1001/archopht.1993.01090040087038

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Article

Leber's hereditary optic neuropathy. Clinical manifestations of the 14484 mutation.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Apr 1993

Johns D R, Heher K L, Miller N R, Smith K H

Abstract excerpt

OBJECTIVE: To define the clinical features of Leber's hereditary optic neuropathy associated with the 14484 mitochondrial DNA mutation and to compare these features with those associated with three other pathogenetic mutations. DESIGN AND PATIENTS: Clinical and historical data were collected from...

Topics

Adolescent
Adult
Base Sequence
Child
DNA, Mitochondrial
Female
Follow-Up Studies
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Optic Atrophies, Hereditary
Pedigree
Polymerase Chain Reaction
Prognosis
Visual Acuity

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