Leber's hereditary optic neuropathy. New genetic considerations.

doi:10.1001/archneur.1993.00540050082021

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Article

Leber's hereditary optic neuropathy. New genetic considerations.

Archives of neurology - 1 May 1993

Newman N J

Abstract excerpt

OBJECTIVE: Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease that causes bilateral central visual loss, predominantly in young men. Recently, this disorder has been associated with point mutations in the mitochondrial genome. The clinical characteristics of LHON are rev...

Topics

Adolescent
Adult
Child
DNA, Mitochondrial
Female
Genome, Human
Humans
Male
Middle Aged
Mutation
Optic Atrophies, Hereditary
Visual Fields

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