In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

doi:10.1289/ehp.9399135

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Article

In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

Environmental health perspectives - 1 Mar 1993

Albertini R J, Nicklas J A, Fuscoe J C, Skopek T R, Branda R F, O'Neill J P

Abstract excerpt

Mutations arising in vivo in recorder genes of human blood cells provide biomarkers for molecular epidemiology by serving as surrogates for cancer-causing genetic changes. Current markers include mutations of the glycophorin-A (GPA) or hemoglobin (Hb) genes, measured in red blood cells, or mutati...

Topics

Antineoplastic Agents
Blood Cells
Environmental Exposure
Epidemiologic Methods
Genes
Genetic Markers
HLA Antigens
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
Neoplasms
Smoking

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