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Article

Effects of Platelet-Derived Growth Factor Isoforms on Human Lung Fibroblast Proliferation and Procollagen Gene Expression

1 Jan 1993

Abstract excerpt

Platelet-derived growth factor (PDGF), a potent mitogen for fibroblasts, is a potentially important cytokine in the pathogenesis of fibroproliferative disorders of lung. Different isoforms of PDGF include a heterodimer composed of A and B chains and homodimers composed of A or B chains. The biological significance of the different isoforms is unknown, but they have been shown to differ in their mitogenic potency...

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PMID: 8319603
DOI: 10.3109/01902149309064350

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