Article
In vitro procollagen synthesis and proliferative phenotype of bronchial fibroblasts from normal and asthmatic subjects.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 1998
Dubé J, Chakir J, Laviolette M, Saint Martin S, Boutet M, Desrochers C, Auger F, Boulet L P
Abstract excerpt
Asthma is characterized histologically by a bronchial subepithelial fibrosis. Cytokines and other mediators released in the asthmatic chronic inflammatory microenvironment can activate the repair process that leads to fibroblast proliferation and collagen synthesis. To our knowledge, there are no data regarding the effect of a chronic inflammatory microenvironment on the phenotype of human bronchial fibroblasts....
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