Article
Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways.
The Journal of biological chemistry - 13 May 1994
Seifert R A, Coats S A, Raines E W, Ross R, Bowen-Pope D F
Abstract excerpt
Mitogenic stimulation of connective tissue cells by transforming growth factor-beta (TGF-beta) has two unusual properties; entry into S-phase is delayed compared with that induced by other mitogens, and the dose response is biphasic, with low concentrations stimulating and high concentrations inhibiting or having no effect. A hypothesis that provides an explanation for both of these properties is that TGF-beta...
Topics
- 3T3 Cells
- Animals
- Cell Line
- Growth Substances
- Interleukin-1
- Mice
- Mice, Inbred C57BL
- Mutation
- Platelet-Derived Growth Factor
- Receptors, Platelet-Derived Growth Factor