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Article

Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

23 Dec 2019

Abstract excerpt

Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified...

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PMID: 31868592
DOI: 10.7554/elife.50047

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