Article
Genetic analysis of Creutzfeldt-Jakob disease and related disorders.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994
Goldfarb L G, Brown P, Cervenakova L, Gajdusek D C
Abstract excerpt
Genetic studies of over 200 cases of Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru have brought a reliable body of evidence that the familial forms of CJD and all known cases of GSS and FFI are linked to germline mutations in the coding region of the PRNP gene on chromosome 20, either point substitutions or expansion of the number of...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Amyloid
- Base Sequence
- Creutzfeldt-Jakob Syndrome
- DNA
- Humans
- Microscopy, Electron
- Middle Aged
- Molecular Sequence Data