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Article

Two molecular pathways to transitional cell carcinoma of the bladder.

Cancer research - 1 Feb 1994

Spruck C H, Ohneseit P F, Gonzalez-Zulueta M, Esrig D, Miyao N, Tsai Y C, Lerner S P, Schmütte C, Yang A S, Cote R

Abstract excerpt

Noninvasive transitional cell carcinomas of the bladder can have two distinct morphologies suggesting they contain different genetic alterations. Papillary transitional cell carcinomas (T(a) tumors) are often multifocal and only occasionally progress, whereas flat tumors (carcinomas in situ, CIS), frequently progress to invasive disease. We examined 216 bladder tumors of various stages and histopathologies for...

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PMID: 8306342

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