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Article

Methylenetetrahydrofolate reductase: a common human polymorphism and its biochemical implications.

Chemical record (New York, N.Y.) - 1 Jan 2002

Matthews Rowena G

Abstract excerpt

Methlenetetrahydrofolate (CH2-H4folate) is required for the conversion of homocysteine to methionine and of dUMP to dTMP in support of DNA synthesis, and also serves as a major source of one carbon unit for purine biosynthesis. This review presents biochemical studies of a human polymorphism in methylenetetrahydrofolate reductase, which catalyzes the reaction shown below. The mutation decreases the flux of...

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Share to Amino Acid Substitution
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Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

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Source

Identifiers

PMID: 11933257
DOI: 10.1002/tcr.10006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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