Cytotoxic susceptibility and defective MHC class I expression do not correlate with mutation of p53 in human carcinomas.

doi:10.1007/BF01517173

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Article

Cytotoxic susceptibility and defective MHC class I expression do not correlate with mutation of p53 in human carcinomas.

Cancer immunology, immunotherapy : CII - 1 Jan 1994

Végh Z, Wang P, Vánky F, Hising C, Sjöwall K, Larsson B, Klein E

Abstract excerpt

Twenty-nine samples of ex vivo ovarian and lung carcinomas were investigated for the relationship between the presence of mutated protein 53 (mp53) and cytotoxic susceptibility. Unaltered expression of MHC class I alleles was required for the cytotoxic susceptibility of tumour cells to the autolo...

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